North Quay in Douglas will be closed to traffic every evening for two weeks from this weekend.
The aim is to encourage more people to visit the area's restaurants, cafes and bars during the Festival of Motorcycling.
The Department of Infrastructure has written to residents and businesses in the area. If the pedestrianisation is successful it could be repeated for other events.
DOI Minister Phil Gawne said: 'This latest initiative is one of the many ways in which the department is contributing to Government’s national priority of growing the economy. We are working in partnership with the business community to help support one of the Island’s key commercial areas.
'Pedestrianising the quayside during the evenings will hopefully encourage more people to visit the establishments and enjoy the ambience this location has to offer.'
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