In Rugby, South Lancashire and Cheshire Division Three leaders Ramsey play their penultimate home match of the season.
The fixture list was kind to the northerners before Christmas but will be on the road for the majority of the remaining campaign.
Their opponents are Linley and Kidsgrove who they beat off-island 30-27.
Home points are a must with so many away trips to come.
In Division One, Douglas are away to Anselmians with both sides looking to cement mid-table positions.
In Division Two, Vagabonds have a tough home match against second-placed Southport at Ballafletcher.
Unbeaten Southern Nomads travel to Douglas "B" in the Manx Trophy while Emerging Nomads play Ramsey "B" in the Manx Bowl.