In Rugby's South Lancashire & Cheshire Division One, Douglas travel away to Manchester after last Saturday's Autumn international break.
Douglas have struggled this term with three wins from eight played.
In Division Two, Vagabonds will be hoping for a 6th win of the season when they welcome Ashton on Mersey to Ballafletcher.
Division Three leaders Ramsey have had their lead trimmed to eight points and will want to consolidate their advantage at home to Oxton Parkonians.
In the Manx Shield, the top fixture is at Port-e-Chee where Douglas "B" welcome Southern Nomads.
Emerging Nomads are at home to Western Vikings.
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