In Rugby, Douglas face a tough trip to unbeaten Winnington Park in South Lancashire & Cheshire Division One.
Winnington Park have won all four games so far including home victories over Hoylake and Glossop.
Douglas recorded a narrow win over Glossop last Saturday.
In Division Two, Vagabonds are also on the road and play at Port Sunlight.
Vagas have been free-scoring in the opening three fixtures and this will be their third away game of the season.
In the Manx Shield, Douglas "B" visit Ramsey "B" and Castletown play Southern Nomads.
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